A deadly wrong-way crash on the southbound 405 Freeway in Sherman Oaks shut down traffic on all lanes early Tuesday.
A SigAlert has been issued in the area between Ventura and Sepulveda boulevards.
Images from NewsChopper4 showed traffic completely stopped and backed up to Roscoe Boulevard.
At around 6:30 a.m., the two right lanes were open to traffic.
According to the SigAlert website, drivers can expect a delay of up to two hours.
Source: NBC Los Angeles